Little Misfortune features Misfortune Ramirez Hernandez, an imaginative eight-year-old girl who is seeking "eternal joy" (Eternal Happiness) as a gift to her mother. Led by her good friend Mr. Voice, she ventures into the woods to uncover the secrets behind the mystery, which also reveals a hint of bad luck. The game takes place under the same worldview as the cult game Fran Bow "Fran's Tragic Journey" and is presented by the visionary game development team Killmonday Games.